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Upon entry into the target cell, the viral RNA genome is converted (reverse transcribed) into double-stranded DNA by a virally encoded reverse transcriptase that is transported along with the viral genome in the virus particle.The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded integrase and host co-factors.They represent approximately 1 in 300 infected persons.HIV is transmitted by three main routes: sexual contact, significant exposure to infected body fluids or tissues, and from mother to child during pregnancy, delivery, or breastfeeding (known as vertical transmission).As the infection progresses, it interferes more with the immune system, increasing the risk of common infections like tuberculosis, as well as other opportunistic infections, and tumors that rarely affect people who have working immune systems.Due to their nonspecific character, these symptoms are not often recognized as signs of HIV infection.



T cells are essential to the immune response and without them, the body cannot fight infections or kill cancerous cells.The World Health Organization recommends treating all children less than 5 years of age; children above 5 are treated like adults.Measures to prevent opportunistic infections are effective in many people with HIV/AIDS.Blood-borne transmission can be through needle-sharing during intravenous drug use, needle stick injury, transfusion of contaminated blood or blood product, or medical injections with unsterilized equipment.

The risk from sharing a needle during drug injection is between 0.63 and 2.4% per act, with an average of 0.8%.

and is frequently associated with adverse effects—where zidovudine is used, about 70% of cases result in adverse effects such as nausea (24%), fatigue (22%), emotional distress (13%) and headaches (9%).


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